Cardiolipin Antibodies (ACA) (IgA / I gG / IgM) Lab Test

Anticardiolipin Antibodies (ACLA),
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Clinical Definition of Cardiolipin Antibodies (ACA) (IgA / I gG / IgM)

Anticardiolipin antibodies are related with thrombocytopenia, recurrent miscarriages, and premature labor and preeclampsia. Anti-cardiolipin antibodies (ACA) are adopted autoantibodies against cardiolipins. Created by the immune system, they are against their own cells, tissues, and organs and attack them causing inflammation & damage.

They increase the patient's risk of developing recurrent unfitting blood clots in the blood vessels. Cardiolipin antibodies are also associated with thrombocytopenia, recurrent miscarriages, and with premature labor and preeclampsia. Anti-cardiolipin antibodies can be classified as IgA; IgG; IgM

When do you expect results?

24 to 36 Hours

Why Get Tested?

The Anticardiolipin Antibodies test detects the cardiolipin antibodies IgA/ IgG/ IgM existence which is an essential process in the body's ability to regulate blood clotting.

It helps diagnose an incongruous blood clot which may cause recurrent miscarriages, thrombocytopenia, unexplained thrombotic episode, a prolonged PTT (activated partial thromboplastin time), hemolytic anemia, thrombotic microangiopathy, SLE or other autoimmune disorders.

Reason to take Cardiolipin Antibodies (ACA) (IgA / I gG / IgM) Test

Symptoms observed in this scenario are recurrent unexplained thrombotic episodes, pain and swelling due to the thrombotic episodes in the extremities, shortness of breath, headaches and recurrent miscarriages during the 2nd and 3rd trimesters.

Preparations Needed for Cardiolipin Antibodies (ACA) (IgA / I gG / IgM) Test

Preparatory instructions during specimen collection*:

No Fasting Required.

No other special preparations required.

Sample Required?

"Specimen type: Serum (Blood Sample)

Specimen collection procedure: Venipuncture (Collection of blood from a vein, usually from the arm)"

Understanding results of Cardiolipin Antibodies (ACA) (IgA / I gG / IgM)

Reference RangeInterpretation
15-19 GPLIndeterminate
0-14 GPLNegative
81 APL or aboveHigh Positive
20-80 APLLow to Medium positive
12-19 APLIndeterminate
0-11 APLNegative
20-80 MPLLow to Medium positive
81 MPL or aboveHigh Positive
20-80 GPLLow to Medium positive
81 APL or aboveHigh Positive
0-12 MPLNegative
13-19 MPLIndeterminate

A Reference range is a set of values which helps the healthcare professional to interpret a medical test. It may vary with age, gender, and other factors. Reference ranges may also vary between labs, in value & units depending on instruments used and method of establishment of reference ranges.

References

  1. https://cvi.asm.org/content/6/6/775
  2. http://www.hopkinslupus.org/lupus-tests/antiphospholipid-antibodies/
  3. https://labtestsonline.org/tests/cardiolipin-antibodies
  4. http://www.ncbi.nlm.nih.gov/pubmed/1415304