Apolipoprotein A1 (APOA / APO-A1) Lab Test

Apolipoprotein A1 (APOA / APO-A1)
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Clinical Definition of Apolipoprotein A1 (APOA / APO-A1)

Apolipoprotein A-I (Apo-A1) is a structural and functional protein that constitutes approximately 70% of the protein in high density lipoprotein HDL.

They are proteins that bind to lipids to form lipoproteins. They help to transport the lipids through the lymphatic and circulatory systems. Their synthesis in the liver is controlled by a host of factors, including dietary composition, hormones (insulin, glucagon, thyroxin, estrogens, and androgens), alcohol intake, and various drugs (statins, niacin, and fibric acids).

Apolipoprotein A-I is a relatively abundant plasma protein and is encoded by the APOA1 gene. It is the major protein component of HDL (High-density lipoprotein) or 'good cholesterol' and has a specific role in lipid metabolism and anticlotting effect of the body. Defects in the gene encoding it are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis.

When do you expect results?

24 to 36 Hours

Why Get Tested?

 

The Apolipoprotein A-1 blood test asseses survival rate or risk factors in individuals who have suffered prior heart attacks, peripheral vascular diseases and hyperlipidemia. Apo A-I levels may also be ordered to help diagnose conditions that cause Apo A-I deficiencies and may be used to monitor the effectiveness of lifestyle changes and lipid treatments.

Apo A-1 recycles cholesterol from the tissues back to the liver for further processing. It keeps the arteries clear of plaque-forming cholesterol. Exciting new research suggests that Apolipoprotein A-1 blood levels may be a better indicator of atherosclerosis and coronary artery disease (CAD) than the traditional cholesterol tests for high-density lipoprotein (HDL), low-density lipoprotein (LDL) and very-low-density lipoprotein (VLDL).

 

Reason to take Apolipoprotein A1 (APOA / APO-A1) Test

Symptoms commonly observed are heartburn or indigestion, pain in the arm (more commonly the left arm, but may be either arm), shortness of breath, headaches, upper back pain, general malaise (vague feeling of illness), Pain, fullness, and/or squeezing sensation of the chest, jaw pain, toothache, nausea, vomiting, and/or general epigastric (upper middle abdomen) discomfort and sweating.

Preparations Needed for Apolipoprotein A1 (APOA / APO-A1) Test

Preparatory instructions during specimen collection:Fasting Required.
Fasting samples have to be collected after a minimum 12-14 hour overnight fasting status.
Clear fluids like water is allowed during this period. Refrain from consumption of early morning beverages like tea, coffee and milk until specimen collection is completed.
In case of diabetics on oral or injectable hypoglycemic agents, consult your physician about continuing with these medications prior to specimen collection.

Sample Required?

Specimen type:Serum (Blood Sample)

Specimen collection procedure:Venipuncture - Collection of blood from a vein, usually from the arm.

Understanding results of Apolipoprotein A1 (APOA / APO-A1)

Reference RangeInterpretation
Male:94-178 mg/dL
Female:101-199 mg/dL

‘*A Reference range is a set of values which helps the healthcare professional to interpret a medical test. It may vary with age, gender, and other factors. Reference ranges may also vary between labs, in value & units depending on instruments used and method of establishment of reference ranges’

References

  1. https://www.labtestsonline.org.au/learning/test-index/apoa
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749415/
  3. http://www.jlr.org/content/50/7/1497.full