MPO (p ANCA) Lab Test

Myeloperoxidase Antibodies, P- Antineutrophil Cytoplasmic Antibodies
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What is MPO (p ANCA)

Myeloperoxidase (MPO) is a peroxidase enzyme vastly existent in neutrophil granulocytes (a subtype of white blood cells). Myeloperoxidase deficiency is a hereditary deficiency of the enzyme which predisposes into immune deficiency.

MPO levels in the blood are observed to be a risk factor for atherosclerosis, coronary artery disease, myocardial infarction and other adverse cardiac events including severe chest pain. Antibodies against MPO are noted in different types of Vasculitis like Crescentic Glomerulonephritis and Churg- Strauss Syndrome. They are diagnosed as Perinuclear ANCAS (pANCAs).

How does MPOs work?

MPOs are a heme containing enzyme that aids the killing of various microorganisms with the help of peroxide and halide ions. Besides that MPOs are also responsible for performing varied extracellular functions.

What is myeloperoxidase test?

Myeloperoxidase Test also known as MPO Blood test helps determine the MPO levels in blood. The MPO test is used for the evaluation of inflammation and infection. The MPO lab test is used conjunction with few other tests like, Electrocardiogram (ECG) and/or cardiac biomarkers test, when a person shows the following symptoms;

  • Chest pain
  • Fever
  • Abnormal heart rate
  • Fatigue and headache
  • Redness

If the myeloperoxidase test comes at a higher value, greater than 539 pM, then it might be an indication for the following conditions;

  • Atherosclerotic plaque instability
  • Inflammation
  • Myocardial infarction

However, the MPO lab test findings are not considered as stand alone tests and rather the MPO test results are interpreted with proper correlation to clinical findings and additional supplementary tests.

When do you expect results?

The MPO Lab test results are usually made available within 24 to 36 Hours

Why Get Tested?

The MPO is ordered to detect any autoimmune disorders like Wegner’s Granulomatosis (WG), microscopic Polyangitis (MPA).

Reason to take MPO (p ANCA) Test

The MPO test is useful in the evaluation of patients suspected of being affected with immune – mediated vasculitis, especially microscopic polyangiitis. Symptoms observed in early stages of the suspected conditions are:

  • Fever
  • Fatigue
  • Weight loss
  • Muscle and or/joint aches
  • Night sweats

As the disease progresses, damage to blood vessels throughout the body cause the following signs and symptoms:

  • Eyes — red, itchy eyes or "pink eye" (conjunctivitis); problems with sight (blurry vision, loss of vision)
  • Ears — hearing loss
  • Nose — runny nose or other persistent upper respiratory symptoms that do not go away
  • Skin — rashes and/or granulomas
  • Lungs — cough and/or difficulty breathing
  • Kidneys — abnormal amounts of protein in the urine

Preparations Needed for MPO (p ANCA) Test

Preparatory instructions before the test *:

No Fasting Required.

No other special preparations required.

Sample Required?

Specimen type: Serum (Blood Sample)

Specimen collection procedure:Venipuncture (Collection of blood from a vein, usually from the arm)

How can we help?

The Myeloperoxidase test is a simple blood test that involves blood sample collection, which can easily be done at home by availing our highly reliable at – home healthcare service. Under this service our representative healthcare professional would visit you at your home to collect the blood sample at a time and date comfortable to you.

Our services not only ends there but, after the lab testing of your blood sample we would also home deliver the myeloperoxidase test report to you. So, take advantage of our economical yet superior standard at- home healthcare service and get pampered with world class healthcare service at the comfort of your home.

Understanding results of MPO (p ANCA)

Reference RangeInterpretation
Below 20 RU/mlNegative
20 and above RU/mlPositive

‘*A Reference range is a set of values which helps the healthcare professional to interpret a medical test. It may vary with age, gender, and other factors. Reference ranges may also vary between labs, in value & units depending on instruments used and method of establishment of reference ranges'

References

  1. https://labtestsonline.org/tests/ancampopr3-antibodies
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2684710/
  3. https://my.clevelandclinic.org/health/diagnostics/16792-blood-tests-to-determine-risk-of-coronary-artery-disease
  4. http://diabetes.diabetesjournals.org/content/63/12/4001