PR3 (c ANCA) Lab Test

C- Antineutrophil Cytoplasmic Antibodies, Serine Protease 3
Book Lab Test At Home
*I authorize Portea representative to contact me. I understand that this will override the DND status on my mobile number.

Clinical Definition of PR3 (c ANCA)

Antineutrophil cytoplasmic antibodies (ANCA) are a set of autoantibodies developed when an individuals immune system wrongly aims and strikes the neutrophil protein, proteinase 3 (PR3). This concludes in the development of autoantibodies to PR3. The PR3 (C-ANCA) blood test diagnosis the presence or absence of these autoantibodies. These autoantibodies exist in a number of autoimmune disorders that are the reason of swelling, harm and injure blood vessels throughout the body (systemic vasculitis). Vasculitis causes tissue and organ damage because of the narrowing and obstruction of blood vessels and the subsequent loss of blood supply.

When do you expect results?

24 to 36 Hours

Why Get Tested?

A PR3 detects and analyses systemic autoimmune Vasculitis and other autoimmune disorders such as Wegener's Granulomatosis (WG), Microscopic Polyangitis (MPA) and other such diseases.

Reason to take PR3 (c ANCA) Test

Common signs observed are:

Conjunctivitis

General vision problems like blurry eyes or a loss of vision

A runny nose or other persistent upper respiratory symptoms that linger for a prolonged duration. 

Abnormal amounts of protein in the urine, rashes and/or granulomas

Hearing loss

Cough and/or difficulty breathing

Muscle aches, night sweats, fatigue, fever and weight loss

Preparations Needed for PR3 (c ANCA) Test

Preparatory instructions during specimen collection*:No Fasting Required.

No other special preparations required.

Sample Required?

Specimen type:Serum(Blood Sample),

Specimen collection procedure:Venipuncture(Collection of blood from a vein, usually from the arm)

Understanding results of PR3 (c ANCA)

Reference RangeInterpretation
20 & Above RU/mLPositive
Below 20 RU/mL **Negative

‘*A Reference range is a set of values which helps the healthcare professional to interpret a medical test. It may vary with age, gender, and other factors. Reference ranges may also vary between labs, in value & units depending on instruments used and method of establishment of reference ranges’

References

  1. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2684710/
  2. http://www.vasculitis.org.uk/about-vasculitis/what-is-anca
  3. http://www.clinexprheumatol.org/article.asp?a=3375
  4. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC130013/
  5. https://labtestsonline.org/tests/ancampopr3-antibodies
  6. https://jasn.asnjournals.org/content/26/10/2314.full.pdf