17 oh progesterone Test


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clinical definition of 17 oh progesterone

17_OH Progesterone blood test (17-OHP) is used in the diagnosis and monitoring of congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency and in the identification of heterozygotes and diagnosis of mild, also referred to as late-onset and cryptic forms of CAH.

The hormone 17-hydroxyprogesterone is a building block for producing the hormone cortisol. Cortisol is produced mainly by the adrenal cortex (the outer part of the two adrenal glands located above the kidneys). Cortisol is called the "stress hormone" because it's secreted in large amounts as part of the body's response to physical or emotional stress. 

what is 17 oh progesterone test?

Progesterone test checks the level of 17-hydroxyprogesterone. To understand better, you must know Progesterone meaning and Progesterone function.

Progesterone meaning

Progesterone is a steroid and natural sex hormone, mainly associated with reproduction. There are many more Progesterone functions. 

Progesterone function

Progesterone functions and benefits of progesterone are seen in:

• Brain functions.

• Hormonal functions.

• Female breast functions.

• Skin health.

• Libido functions.

• Ageing process.

• Substance abuse improvement.

• Sperm development.

• Another steroid

• Stress control.


Now that you know Progesterone meaning and Progesterone function you must know about Progesterone uses. 

Vital uses and benefits of Progesterone:

• Used in menopausal hormone therapy.

• Used in insulin release, diabetes and pancreatic functions.

• Cocaine addiction control is among Progesterone uses.

• Used in stem cell Stems cells are used in vital medical therapies like cancer.

• Progesterone controls spasms.

• Relaxes muscles.

• Anti-inflammatory agent.

• Gall-bladder functions.

• Regulates the immunity system; blood clots, zinc, copper, cell oxygen levels; and fat storage.

• Possibly prevents endometrial cancer.


Other than its uses in its natural form, Progesterone supplements (topical creams, oral medicines, suppositories) are also used to increase Progesterone levels. However, do not use Progesterone supplements suspecting high Progesterone symptoms or Progesterone deficiency. Consult a doctor because there are Progesterone side effects; some can be serious. Here are some common Progesterone side effects; the list is not exhaustive:


• Dizziness

• A headache

• Breast, joint pain

• Mood swings

• Breathlessness

• Stomach problems

• Swollen body parts

• Hot flashes

• Vaginal discharge


Consult a doctor immediately in such cases.

why get tested?

This Progesterone blood test is used to identify people who have nonclassical adrenal hyperplasia. This condition occurs when the body does not make enough of a substance that helps the adrenal gland make cortisol. This test is mainly to check infants for an inherited disorder that affects the adrenal gland, called Congenital Adrenal Hyperplasia (CAH).

It is often performed on adults to rule out any hormonal issues, especially in women to rule out cases of PCOS. Also, infants who are born with outer genitals that do not clearly look like those of a boy or a girl. Women who have excess hair growth in places where adult men grow hair or are found to have any male characteristics, such as a deep voice or an increase in muscle mass.

reason to take 17 oh progesterone test

17 OH Progesterone is needed if there are common signs and symptoms like "salt-wasting" - dehydration, vomiting, listlessness; ambiguous genitalia in female infants; precociousness or failure of puberty and ovulation/menstrual irregularity; and virilisation.

If there are other high Progesterone symptoms like weight gain, drowsiness, depression, dizziness, discomfort in legs, and libido problems.

does 17 oh progesterone test pose any risk?

There are no risks. Usual blood test side effects may occur in very rare cases.

how is 17-oh progesterone test done?

A 17-OH progesterone test is like a normal blood test. In infants, blood is taken with a simple prick in the heel.

how do i prepare for 17-oh progesterone test?

Preparations Needed for 17 OH Progesterone Test:


• No Fasting Required.

• No other special preparations required. 

what might affect my test results?

Corticosteroids, birth control pills may impact results. Please ask your doctor if you should stop them before the test. The time of the test also matters because results are sensitive to natural physical and psychological fluctuations in 24-hours. The blood is collected at a certain time during the female menstrual cycle.

sample required?

Specimen type for 17 OH Progesterone: Serum (Blood Sample), Specimen collection procedure: Venipuncture Collection of blood from a vein, usually from the arm

when do you expect results?

Progesterone test results come in 24 to 36 Hours.

what do my test results mean?

Increased Progesterone could indicate CAH or adrenal tumour. Progesterone deficiency could indicate different problems in men and women. Please consult a doctor for a diagnosis.

what other tests might i have along with 17-oh progesterone test?

Other tests related to Progesterone blood test


Lead (Pb)

Total T4 (Total Thyroxine)

Understanding results of17 OH Progesterone

Reference RangeInterpretation
19.6 to 54.3 pg/mlabnormal

'*A Reference range is a set of values which helps the healthcare professional to interpret a medical test. It may vary with age, gender, and other factors. Reference ranges may also vary between labs, in value & units depending on instruments used and method of establishment of reference ranges’


Whether you have progesterone deficiency or excess, please consult doctors for treatment. Progesterone supplements (mentioned before) and hormone therapy can help. But never take them yourself due to Progesterone side effects.