CA 15.3 (Cancer antigen-Breast 15.3) Lab Test

CA 15.3 (Cancer antigen-Breast 15.3)
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Clinical Definition of CA 15.3 (Cancer antigen-Breast 15.3)

Cancer antigen 15-3 (CA15-3) is a protein produced by a variety of cells, particularly breast cancer cells. There is an increased production of CA 15-3 in persons with cancerous breast tumors however CA 15.3 test is not specific for breast cancer because levels are also increased in patients with gastric, colorectal, lung, pancreas, ovarian, uterine, and cervical cancers. CA 15.3 does not cause cancer.

When do you expect results?

24 to 36 Hours

Why Get Tested?

CA 15-3 concentrations generally increase as the cancer spreads. The highest levels of CA 15.3 are observed when the cancer has spread to the bones and liver. CA- 15.3 test determines the cancer characteristics to monitor the response to treatment of invasive breast cancer and to watch for the recurrence of the disease.

Increasing concentrations of CA- 15.3 over time indicate that person is not responding to treatment or that the cancer is recurring.

Reason to take CA 15.3 (Cancer antigen-Breast 15.3) Test

Common symptoms are 

  • Lumps that are painless, hard, and has uneven edges
  • Breast pain
  • Nipple pain or the nipple turning inward
  • Paget's disease of the breast
  • Lump or mass in the breast
  •  Redness, scaliness, or thickening of the nipple or breast skin, nipple discharge other than breast milk and swelling of all or part of the breast.

Preparations Needed for CA 15.3 (Cancer antigen-Breast 15.3) Test

Preparatory instructions before the test *:

No Fasting Required.
No other special preparations required.

Sample Required?

Specimen type: Serum (Blood Sample)

Specimen collection procedure: Venipuncture (Collection of blood from a vein, usually from the arm)

Understanding results of CA 15.3 (Cancer antigen-Breast 15.3)

Reference RangeInterpretation
00 to 32.4 U/mlNormal

‘*A Reference range is a set of values which helps the healthcare professional to interpret a medical test. It may vary with age, gender, and other factors. Reference ranges may also vary between labs, in value & units depending on instruments used and method of establishment of reference ranges’

 

References

  1. https://www.science.gov/topicpages/c/ca15-3+il-8+levels
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620216/
  3. https://clinicaltrials.gov/ct2/show/NCT00549822
  4. https://www.ncbi.nlm.nih.gov/pubmed/8010729